Acute myeloid leukemia
Acute myeloid leukemia is a clonal proliferation of myeloid precursors that fails to differentiate, defined by myeloblasts at or above 20% of the bone marrow or blood, and it presents with cytopenias from marrow replacement plus, in acute promyelocytic leukemia, a coagulopathic emergency. Diagnosis rests on marrow blast count, immunophenotype, and cytogenetic and molecular testing that set both classification and risk, while treatment is intensive induction chemotherapy or ATRA-arsenic trioxide for APL, followed by risk-adapted consolidation.
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What this article covers
- Overview
Definition: acute myeloid leukemia (AML) is a clonal hematologic malignancy in which myeloid precursor cells proliferate uncontrollably and fail to differentiate normally, infiltrating the marrow…
- Epidemiology
Predominant acute leukemia of adulthood: AML is more common than ALL in adults, the reverse of the pattern in children.
- Risk factors
Prior cytotoxic exposure: alkylating chemotherapy and ionizing radiation are established causes of therapy-related AML.
- Pathophysiology
Clonal block in differentiation: a myeloid progenitor acquires mutations that arrest maturation at an immature blast stage while proliferation continues unchecked.
- Clinical features
Cytopenia-driven symptoms, the most common presentation: fatigue and dyspnea from anemia; fever and infection from functional neutropenia despite a potentially high total leukocyte count; petechiae…
- Differential diagnosis
Acute promyelocytic leukemia is a distinct, high-urgency AML subtype rather than a separate mimic, distinguished by t(15;17) PML-RARA, hypergranular promyelocytes, and DIC at presentation, and must…
- Diagnosis
The diagnosis is established by myeloblasts at or above 20% of the bone marrow or peripheral blood (WHO criteria): this threshold, on either compartment, defines AML and separates it from MDS (fewer…
- Management
Assess and stabilize first: correct severe cytopenias, evaluate for DIC, hyperleukocytosis, tumor lysis risk, and infection, and determine fitness for intensive therapy.
- Complications
Hemorrhage and DIC: the dominant early cause of death in APL if ATRA is delayed; also occurs from severe thrombocytopenia in any AML subtype.
- Prognosis
Overall cure depends on age and fitness: 35% to 40% of adults 60 years or younger achieve cure with intensive therapy, versus only 5% to 15% of adults older than 60, in whom comorbidities frequently…
- Prevention
No primary prevention exists for de novo AML; limit occupational benzene exposure and use the lowest effective doses of alkylating chemotherapy and radiation, since both cause therapy-related AML.
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