Infectious Disease· Topic 7.1 Skin and soft tissue infections· 7.1.23

Animal and human bites

Animal and human bites are contaminated wounds whose organism profile depends on the biter, Pasteurella multocida from cats and dogs, Eikenella corrodens and group A Streptococcus from humans, and every wound needs irrigation plus an independent assessment for rabies and tetanus risk. First-line prophylaxis or treatment is amoxicillin-clavulanate 875/125 mg PO every 12 hours, with human and cat bites carrying the highest infection risk and any hand or joint-adjacent wound treated as high risk for septic arthritis or osteomyelitis.

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What this article covers

  • Overview

    Definition: animal and human bites are contaminated, often crush-and-tear wounds inoculated with the biting mouth's oral flora and the victim's own skin flora.

  • Epidemiology

    Risk of infection by source: human bites carry the highest risk of infection, followed by cat bites, then dog bites, reflecting the density and pathogenicity of the inoculated oral flora.

  • Risk factors

    Bite by a human or a cat: confers the highest infection risk among common bite sources.

  • Pathophysiology

    Inoculation of oral flora into torn tissue: crush injury, laceration, and direct inoculation with the biting mouth's flora together favor both aerobic and anaerobic infection.

  • Clinical features

    Visible puncture, laceration, or crush wound at the bite site, with the biter's identity and the circumstances of the bite determining risk stratification.

  • Differential diagnosis

    Necrotizing fasciitis: unlike bite-wound cellulitis, shows crepitus, spreading discoloration, and pain out of proportion to exam, requiring emergent debridement.

  • Diagnosis

    Diagnosis of an infected bite wound is clinical, based on a bite history plus local erythema, warmth, swelling, and pain; no single test is required, and the workup instead assesses severity and excludes deep-space or bone involvement.

  • Management

    First, irrigate the wound thoroughly to reduce bacterial inoculum before deciding on closure or antibiotics.

  • Complications

    Necrotizing fasciitis: usually from a polymicrobial infection or toxin-producing group A Streptococcus, requiring debridement plus clindamycin and a beta-lactam; mortality is 30% in previously…

  • Prognosis

    Good with prompt irrigation, appropriate antibiotics, and early recognition of deep-space or joint involvement; most bite wounds heal without sequelae.

  • Prevention

    Prophylaxis for all human bites and for animal bites with a high-risk feature (immunocompromise, a wound near a joint or bone, or crush injury/edema), using amoxicillin-clavulanate 875/125 mg PO every 12 hours for 3 to 5 days.

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