Drug-induced myopathy
Drug-induced myopathy spans a spectrum from asymptomatic creatine kinase elevation to rhabdomyolysis and is caused by statins (most common), glucocorticoids, colchicine, hydroxychloroquine, zidovudine, amiodarone, alcohol, and cocaine, each with a distinct mechanism, time course, and presentation. The critical distinction is toxic myopathy that resolves with drug withdrawal versus statin-associated anti-HMGCR necrotizing myopathy, which persists after discontinuation and requires immunosuppression.
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What this article covers
- Overview
Drug-induced myopathy is a spectrum, not one disease: asymptomatic CK elevation and myalgia at the mild end, overt weakness and, rarely, rhabdomyolysis at the severe end.
- Epidemiology
Statins cause the most cases overall: muscle symptoms occur in no more than 1% of users; myopathy and rhabdomyolysis together occur in under 0.1%, usually in the first year after a dose increase or added interacting drug.
- Risk factors
Higher statin dose and lipophilic statins (simvastatin, atorvastatin, lovastatin) exceed hydrophilic agents (rosuvastatin, pravastatin); a CYP3A4 inhibitor or fibrate (fenofibrate, gemfibrozil) raises statin levels further.
- Pathophysiology
Statins usually cause direct toxic myopathy via mevalonate pathway inhibition; a minority instead develop autoimmunity, statin exposure upregulating HMGCR in regenerating fibers and triggering…
- Clinical features
Statin myopathy: symmetric proximal pain and/or weakness (sometimes only nonspecific low back pain), CK up to about 10x the upper limit of normal (ULN), usually within the first year.
- Differential diagnosis
Statin-associated anti-HMGCR necrotizing myopathy: weakness persists after statin withdrawal with markedly elevated CK; the most dangerous mimic to miss, since it needs immunosuppression, not observation.
- Diagnosis
There is no single formal criteria set; diagnosis rests on clinical assessment plus muscle enzymes, EMG, and biopsy when needed, anchored to temporal correlation with a myotoxic agent.
- Management
First, discontinue the offending agent for essentially all causes; this alone resolves most cases over days to weeks.
- Complications
Acute kidney injury from rhabdomyolysis-induced pigment nephropathy, driven by myoglobin-mediated tubular injury and volume depletion; risk rises sharply above CK 5000 U/L.
- Prognosis
Toxic (non-immune) myopathy generally resolves rapidly with discontinuation: statin symptoms and CK typically normalize within weeks.
- Prevention
Do not check baseline CK before starting a statin in an asymptomatic patient; check CK only when muscle pain or weakness develops.
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